Best Hotels South of Indianapolis on I-65

We checked thousands of reviews on and to find the best hotels for your stay
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Lucy Kennedy

Updated: 24 January 2024 · 3 min

Nestled in the center of the Midwest, Indianapolis is a hub of vibrant energy, rich history, and bustling activity that draws visitors from all corners of the globe. Beyond its renowned sports venues, cultural institutions, and culinary delights, the area around Indianapolis offers an array of accommodation options for travelers seeking comfort and convenience. Particularly, the hotels located south of Indianapolis along Interstate 65 provide a strategic and appealing choice for those looking to explore the region or those merely passing through.

The stretch of I-65 south of Indianapolis is dotted with a variety of hotels designed to suit every preference and budget. From luxurious suites offering panoramic views of the rolling Indiana landscapes to cozy, budget-friendly rooms that promise a good night’s sleep, the selection is plentiful. These hotels not only grant easy access to downtown Indianapolis and its attractions but also serve as gateways to the natural beauty and charm of Southern Indiana, making them perfect for both city explorers and nature lovers alike.

Choosing the right hotel in this region can significantly enhance your travel experience, allowing for restful nights and energized days filled with exploration and discovery. Insights into the best accommodations along I-65 can aid travelers in making informed decisions, turning a simple stay into an integral part of their journey. Whether you're in town for business, pleasure, or a bit of both, the hotels south of Indianapolis on I-65 promise a stay that's as rewarding as it is comfortable.
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Our Top 6

(Sorted by rating & number of reviews)

1. Holiday Inn Express & Suites Indianapolis North - Carmel, An Ihg Hotel
2. Fairfield Inn & Suites By Marriott Indianapolis Fishers
3. Keystone Inn & Suites
4. Hampton Inn Indianapolis-South
5. Hilton Garden Inn Indianapolis South/Greenwood
6. Courtyard By Marriott Indianapolis South Hotel

Family-Friendly Hotels South of Indianapolis on I-65

Check Availability

Indianapolis
Dec 06, 2025 - Dec 07, 2025

Holiday Inn Express & Suites Indianapolis North - Carmel, An Ihg Hotel

8.4

Good

(234 Reviews)

+ 103 photos
Nestled just off I-65, the Holiday Inn Express & Suites Indianapolis South provides a convenient and comfortable base for families. With contemporary decor and a suite of modern facilities, this hotel ensures a stay that is both relaxing and engaging. Each room boasts comfortable bedding, a mini-fridge, and a microwave, making in-room meals and snacks a breeze. The indoor pool is a popular feature, offering fun for kids and a relaxing option for parents. The hotel's complimentary Express Start Breakfast bar with a range of hot and cold items ensures that every family member starts the day right. Moreover, its location offers easy access to Indianapolis' kid-friendly attractions, making it an excellent option for family travelers.
Address: 9797 North Michigan Road
Rating: Good 8.4 (234 Reviews)
Rooms: 66
Price: From 167$

Fairfield Inn & Suites By Marriott Indianapolis Fishers

8.8

Good

(138 Reviews)

+ 20 photos
The Fairfield Inn & Suites by Marriott Indianapolis South is a gem for families traveling through the area. This hotel prides itself on creating a homely atmosphere with its comfortable rooms, friendly staff, and thoughtful amenities. Each room is designed with families in mind, offering spacious layouts and convenient facilities. The complimentary breakfast features a variety of healthy and kid-friendly options, ensuring a great start to your day. The indoor pool is another highlight, providing entertainment for kids and a relaxing environment for adults. Situated on I-65, the Fairfield Inn & Suites offers easy access to Indianapolis' plethora of family attractions, making it an ideal choice for those seeking a blend of convenience and comfort.
Address: 10495 Crosspoint Boulevard
Rating: Good 8.8 (138 Reviews)
Rooms: 99
Price: From 169$

Business-Friendly Hotels South of Indianapolis on I-65

Traveling for business necessitates a certain set of requirements from your accommodation: convenience, efficiency, and amenities tailored for work and relaxation. Hotels south of Indianapolis on I-65 cater to business travelers with their strategic location, offering swift access to and from the city. These hotels are designed to meet the needs of the modern professional, featuring business centers, high-speed internet, and comfortable workstations. Additionally, they provide the perfect backdrop for unwinding after a day of meetings, with fitness centers and dining options. The following selections are highly regarded for their commitment to meeting the needs of business travelers.

Keystone Inn & Suites

7.5

Good

(484 Reviews)

+ 61 photos
While not directly off I-65, Hyatt Place Indianapolis/Keystone is located within a reasonable distance for travelers looking for quality accommodations south of Indianapolis with efficient access to the interstate. This hotel is particularly suited for business travelers, offering spacious rooms with a Cozy Corner sleeper sofa and a work desk. Free Wi-Fi and remote printing directly to the business center cater to the needs of those on work trips. Guests can start their day with a complimentary breakfast, including hot and healthy options. For downtime, the indoor pool and 24/7 fitness center provide relaxation and recharging opportunities. Hyatt Place's blend of comfort, convenience, and business amenities makes it a worthy consideration for professionals visiting the area.
Address: 9104 Keystone Crossing
Rating: Good 7.5 (484 Reviews)
Rooms: 6
Price: From 109$

Hampton Inn Indianapolis-South

8.4

Good

(424 Reviews)

+ 75 photos
The Hampton Inn Indianapolis-South is perfectly positioned for families exploring the region. Situated conveniently along I-65, this hotel offers ease of access to downtown Indianapolis while serving as a cozy getaway from the urban hustle. Families will appreciate the spacious rooms equipped with modern amenities, ensuring a comfortable stay for everyone. The complimentary hot breakfast is a hit among all age groups, offering a variety of options to kickstart your day. An indoor pool provides entertainment for children and a relaxing option for adults. Additionally, the hotel's proximity to local attractions and its commitment to providing warm, attentive service make it a top choice for families.
Address: 7045 Mcfarland Blvd.
Rating: Good 8.4 (424 Reviews)
Rooms: 112
Price: From 116$

Mid-Range Hotels for the Leisure and Business Traveler

Mid-range hotels are abundantly available along I-65 south of Indianapolis, catering to both leisure and business travelers. These establishments strike a balance between affordability and luxury, offering guests enhanced amenities like fitness centers, business facilities, indoor pools, and on-site dining options. They are designed to accommodate guests looking for a bit more comfort and convenience in their stay. Whether you're in town for a meeting or exploring Indianapolis and its surroundings, these hotels provide a comfortable base with a touch of extra amenities to make your stay more enjoyable.

Hilton Garden Inn Indianapolis South/Greenwood

8.2

Good

(219 Reviews)

+ 76 photos
The Hilton Garden Inn Indianapolis South/Greenwood is a standout choice for business travelers. Located just off I-65, it offers easy access to downtown Indianapolis and the surrounding business districts. The hotel boasts a 24-hour business center, free high-speed internet, and meeting rooms equipped with the latest technology. Rooms are designed with the business traveler in mind, featuring ergonomic workstations and ample space to relax. The on-site restaurant offers a convenient dining option, while the fitness center is perfect for de-stressing after a day of work. This hotel's blend of business-friendly amenities and prime location makes it a preferred option for those on professional trips.
Address: 5255 Noggle Way
Rating: Good 8.2 (219 Reviews)
Rooms: 135
Price: From 138$

Courtyard By Marriott Indianapolis South Hotel

7.1

Good

(92 Reviews)

+ 45 photos
The Courtyard by Marriott Indianapolis South provides an ideal environment for business travelers, blending comfort and functionality. Situated conveniently near I-65, the hotel allows for easy travel to Indianapolis' business areas. The rooms are equipped with free Wi-Fi and ergonomic workstations, ensuring productivity remains uninterrupted. The on-site business center and meeting rooms are available for any professional needs that may arise. For relaxation, the hotel offers a fitness center and an indoor pool. The Bistro, the hotel's dining option, serves breakfast and dinner, catering to busy schedules with healthy, quick bites. The Courtyard's thoughtful amenities and strategic location make it a reliable choice for business visitors.
Address: 4650 Southport Crossing Drive
Rating: Good 7.1 (92 Reviews)
Rooms: 83
Price: From 159$